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The great detective Hercule Poirot, who was in Istanbul, returns to England on the famous Orient Express, where he seems to be travelling with all possible nationalities. One of the passengers, an unpleasant American named Ratchett, offers Poirot to become his bodyguard, because he believes that he should be killed. The famous Belgian shrugs off this absurd request. And the next day the American is found dead in his compartment, with the doors closed and the window open. Poirot immediately takes up the investigation - and finds out that the coupe is full of all sorts of evidence, indicating ... almost all passengers of the Eastern Express. In addition, the train is stuck in snow drifts in a deserted place. Poirot needs to find the killer before the express continues on its way...